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Psychiatry 31, 535542

doi: 10.1097/NEN.0b013e31816362aa 102 KaliaL

Infection-induced hypoxia and inflammatory stimuli upregulate HIF-1, which then enhances immune cell metabolism and inflammatory responses, while disrupting osteoblast/osteoclast balance to aggravate bone destruction

found that (110), AD can reduce the production of anti-CII, TNF, IL-1 and IL-6 in the serum of CIA mice, and can also decrease the phosphorylation of p38 MAPK and ERK1/2 in RASFs induced by TNF in a dose-dependent manner