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Intrathecal drug delivery in the era of nanomedicine

These findings indicate a kinetic effect of the FAT10 UBL2 domain on the rate-limiting step during initiation rather than a contribution to the binding affinity

The FDA has stated that compounded drugs containing epitalon may pose risks related to immunogenicity, aggregation, and peptide-related impurities, and that the agency lacks sufficient information to know whether the drug would cause harm for the proposed route of administration