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To limit potentially life-threatening depletion of intracellular antioxidant/GSH stores, epithelial cells have developed numerous compensatory pathways, including the cystine-glutamate antiporter (SLC7A11), which critically maintains de novo GSH biosynthesis by increasing intracellular cystine levels (9)

Sports Medicine, 35(4), 339-361

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Other advanced options include the LINX reflux management system and TIF (EsophyX), both designed to strengthen the barrier against reflux with minimal disruption

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[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Sennino B., Ishiguro-Oonuma T., Wei Y., Naylor R.M., Williamson C.W., Bhagwandin V., Tabruyn S.P., You W.K., Chapman H.A., Christensen J.G., et al