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36 Conversely, BMAL1 knockout in chondrocytes ( Col21-CreER, Bmal1 flox/flox ) significantly reduces VEGF and HIF-1 levels while increasing MMP13 and Runx2 expression, ultimately suppressing cell proliferation and promoting apoptosis

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The Buffalo group reported its use in 31 cases at their institution with no associated complications [38]

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Additionally, the CFAX12 system can be adapted to investigate other respiratory diseases and toxic exposures, such as the effects of e-cigarette vapor or heated tobacco products on human lung health

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