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For instance, there have been deaths associated with coffee enemas reported in the U.S.during the 80s

Peer review Peer review information Nature Communications thanks Donat Kgel, Raphal Rodriguez and the other anonymous reviewer(s) for their contribution to the peer review of this work

Terpinen-4-ol is considered to be the main active component but as a great article in Clinical Microbiology Reviews states " while some TTO components may be considered less active, none can be considered inactive " and most components contribute to TTO's strong antibacterial, antiviral and antifungal effects

10.1016/j.cell.2013.04.023 49 Czystowska-KuzmiczM.SosnowskaA.NowisD.RamjiK.SzajnikM.Chlebowska-TuzJ.et al

Functional imaging of focal brain activation in conscious rats: impact of [ 14 C]glucose metabolite spreading and release

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