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Schuijs, Vlaams Instituut voor Biotechnologie, Belgium Updates Copyright 2022 Wang, Zhou, Wang, Fukunaga, Li, Yodoi and Tian

Nozohour et al

6.1 Optimization of pharmacokinetics and nanocarrier delivery Phytochemicals often face significant pharmacokinetic challenges, such as poor solubility, rapid metabolism, and low bioavailability, which severely limit their clinical application

Preclinical research models indicate that MPs/NPs may accelerate both the initiation and progression of PD by facilitating -synuclein misfolding and aggregation, triggering neuroinflammatory cascades, elevating oxidative stress, and impairing mitochondrial function

Support for allicin synthesis was provided by internal funding from the RWTH Aachen University to MG and AS

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