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Mechanism of Action How Dihexa activates the HGF/c-Met pathway to promote synaptogenesis, dendritic spine formation, and long-term potentiation

There are three tyrosine kinase inhibitors (TKIs) which target MET that are currently approved for use as monotherapy in the treatment of cancers - crizotinib (PF-02341066), cabozantinib (XL-184) and capmatinib (INC280)

Once injected, Cagrilintide activates amylin receptors in the hypothalamus, the part of your brain that controls hunger

Lack of specific preclinical disease models The in vitro BBB models, as well as disease models that exist today, are poorly predictive tools