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In a diabetic kidney disease model, it was observed that the renal tissue shows a significant increase in iron ion content, elevated levels of MDA and 4-hydroxynonenal (4-HNE), decreased GSH, markedly decreased FTH1 expression, significantly increased TFR-1 expression

Goldberg MS, Hook SS, Wang AZ, Bulte JWM, Patri AK, Uckun FM, Cryns VL, Hanes J, Akin D, Hall JB, Gharkholo N, Mumper RJ (2013) Biotargeted nanomedicines for cancer: six tenets before you begin