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As noted above, SOD1/2 (Cu/Zn and Mn, respectively), CAT, and GPx catalyze the dismutation of O to O 2 and H 2 O 2 and the subsequent decomposition of the latter to O 2 and H 2 O

Specifically, the GR cooperates with Clock and Bmal1 to co-regulate genes involved in carbohydrate, lipid and amino acid metabolism, including peroxisome proliferator-activated receptor ( PPAR ), CD36 and 4-aminobutyrate aminotransferase

A.FadakaA.OlayideI.et al (2017)

Treatment with mild hypothermia (33C) 20- and 60-min post-MCAO led to a significant reduction in ACs and activated microglia and astrocytes, identified by active caspase-3, anti-CD-68, and glial fibrillary acidic protein (GFAP) immunohistochemistry

Inflaming the Brain with Iron

doi: 10.1038/s41590-020-0666-9