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DNA damage activates PARP1, which quickly uses up NAD+, creating a harmful cycle

10.1177/0022034520949486 127 Moreno-BlasD.Gorostieta-SalasE.Castro-ObregnS

In fact, enzymes involved in neuromuscular activity (i.e., the ATPase enzymes that transport of sodium, potassium, and calcium ions) are apparently most sensitive to magnesium deficiency (69)