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MOTS-c is a mitochondrial-derived peptide (MDP) encoded within the mitochondrial genome that improves cellular energy metabolism, insulin sensitivity, and exercise capacity through AMPK activation and metabolic regulation

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Schoenenberger & Monnier, Progress in Neurobiology (1977) Foundational studies characterising DSIPs role in sleep modulation and associated neurochemical mechanisms

40,41 The endothelial cells in the BBB differ from peripheral endothelial cells in morphology and function

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For instance, BPC-157, a peptide found in gastric proteins, is used mainly for angiogenesis and local signaling studies, while TB-500, a peptide found in Thymosin Beta-4, is mostly used for actin regulation and cell migration