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It is interesting to note that although KO mice for GH receptor/GH binding protein and for GH-releasing hormone showed an extended longevity (250, 251), this effect was not observed when using targeted deletion of the GH receptor in the liver, muscle, or adipose tissue (Table 3) (252)

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We showed that the IGF-1 receptor was widely distributed in the brain and largely coexisted with immature neurons

Given their central role, microglia represent a promising therapeutic target for the treatment of neuropathic pain

The supernatant was reacted with phenyl isothiocyanate, filtered through 0.22 m film, and used for HPLC analysis