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Moreover, preconditioning MSC-EVs with traditional Chinese medicine (TCM) components, such as those from Salvia miltiorrhiza, upregulates hsa-miR-27a-5p_R-1 to modulate the signal transducer and activator of transcription 3 (STAT3)-SHANK2 (SH3 and multiple ankyrin repeat domains protein 2) axis, significantly improving the EVs anti-fibrotic and tissue-repair capabilities [194]

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However, in cases of documented deficiency or increased requirements, appropriate supplementation under professional guidance can help restore optimal levels and reverse related symptoms

The difference between elevated or unchanged GLP-1 levels in obese patients may be related to differences in metabolic status and detection methods, but the significant correlation between GLP-1 and lipid metabolism suggests that it can control weight and regulate lipid metabolism in HF diet groups, and GLP-1 has the potential to treat obesity caused by HF diet [102]

J.SamuelB

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