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These studies mark the first administration of a drug candidate to human subjects and provide the initial clinical evidence needed to guide subsequent phases of development

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TGF- is activated through interactions with glycoprotein A repetitions predominant (GARP), integrins, proteases, and other TGF--binding proteins, enabling its subsequent binding to the TGF- receptor family (TR) [36]

PCD: programmed cell death

This increase in intracellular calcium induces proteolysis by calcium-dependent proteases

3.1 S dng nng vt ngng hp th Vic np qu nhiu hot cht khin c th phi tng cng lm vic o thi lng d tha, i khi gy ra phn ng nng tm thi