interaction of chloroacetamide electrophiles with cellular glutathion An Activity-Guided Map Electrophile-Cysteine Interactions in Primary Human T Cells: Cell Design, synthesis, and biological evaluation

Design, synthesis, and biological evaluation of nitroisoxazole containing spiro[pyrrolidin oxindole] derivatives as novel glutathione peroxidase 4 mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation ScienceDirect Selective covalent targeting of GPX4 using masked nitrile oxide electrophiles Nature Chemical Biology Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS: Cell Chemical Biology Targeting a Therapy Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors bioRxiv New mechanistic insights into halogen dependent cytotoxic pattern of monohaloacetamide disinfection byproducts ScienceDirect Glutathione dynamics in subcellular compartments and implications for drug development ScienceDirect

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