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Although the role of bombesins in modulating mucus secretion or muc5AC/muc5B regulation in COPD is unknown, given that bombesins are increased in COPD [193] and muc5B is also increased [188], then it is possible that either a direct or indirect relationship between bombesin signaling and muc5B expression exists

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Similarly, Cas13-mediated RNA editing experiments for mitochondrial diseases are exhibiting prolonged RNA knockdown without observable off-target consequences, offering clinical validation for transitory, programmable non-coding RNA modification in human tissues

Mathur M, Rizvi TA, Nayak NC

Importantly, AOD9604 achieved these effects without activating the growth-promoting pathways that full-length growth hormone uses, which is why it doesnt cause the unwanted side effects of growth hormone therapy such as insulin resistance or abnormal growth