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TNFR-1 exerts a negative influence on hippocampal adult neurogenesis,656667 whereas TNFR-2 is involved in promoting neurogenesis.6869 TNF- is also closely associated with synaptic plasticity by inducing -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors that mediate glutamatergic activity.70 Because human neural stem cells have both TNFR-1 and TNFR-2, whether neurogenesis is enhanced or inhibited depends on the microenvironment in the CNS and the context of insults

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However, at higher concentrations (4%, v / v ), where the overall cell viability decreased for all samples, liposomal formulations (BPO and BPO-CAM) exhibited similar cytotoxicity, albeit lower than that observed with control drug solutions

Zhang Wen

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However, it has not received approval as a medical product from the US Food and Drug Administration (FDA), and studies on its use in humans are lacking