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Description

Cell 144 , 7991 (2011)

227 :199-203.e1 155

Fan-Jiang PY, Lee PS, Nagabhushanam K, Ho CT, Pan MH

This stability is primarily due to the coordinated actions of DNMT1 and related cofactors, which collectively ensure genomic integrity during development and in response to environmental challenges (Bird, 2002)

Such mutations impair cellular uptake of riboflavin, leading to reduced FMN and FAD synthesis and consequent dysfunction of mitochondrial FAD-dependent enzymes, culminating in axonal degeneration, motor neuron disease, and sensory neuropathy