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The science says: biologically plausible, preclinically promising, mechanistically coherent

Chai SY, Bastias MA, Clune EF, Matsacos DJ, Mustafa T, Lee JH, McDowall SG, Paxinos G, Mendelsohn FA, Albiston AL

Further into the cascade, H2O2, a common reactive oxygen species, activates the small GTPase Ral

The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location

Liz graduated from Pepperdine University with a degree in Biology in 1994

Liu Y, Hou Q, Wang R, Liu Y, Cheng Z (October 2023)