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This work was supported by the Research Project Supported by Shanxi Scholarship Council of China (2020-191), Four Batches Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province (2020SYS08), the Project of Central Guides Local Science and Technology Development Funds (YDZJSX2022C031), the Foundation of Shanxi Key Laboratory for immunomicroecology (202104010910012) and Changes of intestinal microflora in patients with Psoriasis before and after treatment with secuchiumab based on 16S rRNA sequencing (202209)

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However, hyperactivation of PPAR by TZD may induce adipose tissue expansion, weight gain and fatty liver in patients and animals 1,2,3 and adipogenesis in vitro 4,5