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Although normally only active in the presence of low oxygen levels, exposure to the oxygen species H 2 O 2 and HOCl also leads to its activation in several Salmonella enterica species, Haemophilus influenzae and other pathogens [276]

doi:10.1186/s12929-014-0110-2 643. Deng M, Tan X, Peng X, Zheng W, Fu R, Tao S

(2020)) and unpublished data generated after that experimental study, but before the conception of this computational study

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Given the potential clinical benefits of melatonin and its safety, it is a target of choice to counteract oxidative stress and enhance oocyte/embryo quality

Persistent Nrf2 signaling has been associated with enhanced proliferation, metastatic dissemination, and resistance to multiple chemotherapeutic agents