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Studies have shown that mice lacking peroxiredoxin-1 (PRDX1), Cu, Zn-SOD (SOD1) or Mn-SOD (SOD2) present increased incidences of various malignancies (Neumann et al

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doi: 10.1016/j.molcel.2021.12.006 47 ChenSSaeedAFUHLiuQJiangQXuHXiaoGGet al

Although the role of membrane anchors with large spatial separations in kinase activation is unique, similar local rearrangements of the N-lobes and C-lobes of other PIKK family members, ATM, MEC1 ATR and DNA-PK, have been reported in response to reactive oxygen species-dependent activation 34 , constitutive activating mutation (F2244L) 35 and DNA activation 36 , respectively

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When Fas triggers apoptosis in human activated neutrophils, inhibition of the subsequent apoptotic processes may be achieved by increasing the intracellular GSH levels with exogenous GSH