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Instead, research points to the interaction of low MAO-A and childhood neglect or mistreatment in males, increasing the relative risk of aggression.[ref] Really rare mutations that significantly decrease MAOA levels in humans cause a genetic disease called Brunner syndrome, and the symptoms include impulsive and antisocial behavior.[ref] So the effect of low MAOA on impulsivity is real, but it isnt necessarily caused by the common variants that decrease MAOA in all individuals