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These iNs retained the heteroplasmy mutation load from the parent fibroblast and showed features of matured neurons

The degradation of ATP into adenosine, controlled by ectonucleotidases, affects astrocytic tone via adenosine A 1 and A 2A receptors [438]

In biomanufacturing processes, high-producing cell subpopulations may have fitness disadvantages compared to low-producing cells due to the higher metabolic burden, so they may be less active, leading to lower overall product formation

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