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Therefore, the ultimate role of HIF-1 is the result of a complex balance between its direct cell-autonomous inhibitory effects and its indirect, microenvironment-driven pro-osteogenic effects

Gastroenterology 161 , 400404 (2021)

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In parallel with tumor shrinkage, Erastin significantly upregulated the levels of 4-HNE, a lipid peroxidation marker, but not cleaved caspase-3 and Ki67, in LDHB KD tumors, reinforcing the notion that ferroptosis underpins the anti-tumor effects of SLC7A11 inhibition in LDHB KD cancer cells ( Supplementary Figure 9c, e )

10.7666/d.y1399920 Sinularia sp

A deeper meta-genomic insight to assure 3-D structure/function of nutrient molecules, priming/activation of nutrients with co-factors, compositional stoichiometry, optimal milieu (pH, redox, and ionic strengths), molecular interplay between bioactives (synergism/antagonism), target delivery, ADME/Safety/Toxicity profiles, and most importantly the bio-functional activity, are vital prerequisites in the development of nutrient-based remedials to RESET the virus-induced HMRD in long-COVID, the new onset global metabolic syndrome