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Insulin and thyroid hormones are also potent modulators of the HPG axis (2225)

In the PTZ-induced epilepsy model, the upregulation of BDNF suggests its role in the enhancement of glutamatergic response and hindering GABAergic neurotransmission (Nader et al

The result is a systems-level approach to digestive health, with butyrate at the center as the key metabolite.