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Harnessing the mitochondrial integrity for neuroprotection: Therapeutic role of piperine against experimental ischemic stroke

J Lab Clin Med 121:257262 Colombo G, Clerici M, Giustarini D, Portinaro N, Badalamenti S, Rossi R, Milzani A, Dalle-Donne I (2015) A central role for intermolecular dityrosine cross-linking of fibrinogen in high molecular weight advanced oxidation protein product (AOPP) formation

The POR pathway induces lipid peroxidation and ferroptosis in the cells expressing low levels of ALOXs, indicating that targeting POR or CYB5R1 is liable to a more potential therapeutic approach [58]

Additionally, immunofluorescence revealed that CXCL10 antibody treatment in the CM group significantly reversed the MCA205 tumor-induced increase in pro-inflammatory M1 macrophage levels (Fig

Sox2 fl / fl mice (Fig 2A and C) or ablating SOX2 + cells using diphtheria toxin (DTA) expressed under the control of the inducible Sox2 promoter ( Sox2 CreERT2 ;Rosa26 DTA