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A two-pronged approach to inhibit ferroptosis of MSCs caused by the iron overload in postmenopausal osteoporosis and promote osseointegration of titanium implant

Superoxide radicals (O 2 ), a type of ROS generated during metabolic processes, are converted into H 2 O 2 and O 2 by SOD, using metal as a cofactor (187)

Research using compounds such as 4-chlorobenzoic acid has shown that the radiation tolerance of KEAP1, triggered sporadically (in a non-constant manner and under selective pressure), can be enhanced to treat lung tumors with KEAP1 mutations, which is achieved through the sporadic activation of a CoQ-FSP1 antioxidant axis (124)

Ferroptosis: Role of Lipid Peroxidation, Iron and Ferritinophagy

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The investigators concluded that administration of exogenous GSH had a beneficial effect on renal function by virtue of its antioxidant properties, and possibly by a vasodilator action to increase the glomerular filtration rate as well