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When to Stop and Reassess Discontinue creatine and recheck labs in 3 to 4 weeks if: cystatin C-based eGFR drops below 60, serum copper exceeds 140 mcg/dL on two consecutive draws, or unexplained symptoms like peripheral edema or dark urine develop

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According to Professor Adrian R Martineau, 1 March 2015, in his article discussing the main recommendations for healthcare practitioners in NICE Public Health (PH) guidance 56 on Vitamin D: increasing supplement use among at-risk groups: "Health professionals do not need to routinely test vitamin D status in asymptomatic people in at-risk groups before advising them to take a vitamin D supplement