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Effect of high-dose vitamin D supplementation on volumetric bone density and bone strength: A randomized clinical trial

(87) utilized a two-by-two factorial design over 4.6 years with 25,871 middle-aged or older adults, including 1,032 with a history of probable migraine, and found that neither vitamin D nor marine omega-3 PUFAs supplementation affected migraine frequency or severity compared to a placebo

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While some people notice improvements in energy or mental clarity within a few days, it typically takes 2 to 4 weeks of consistent use to see the full benefits

doi: 10.1186/s12876-016-0488-2, 74