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In patients with underlying systemic vasculitis, immunosuppressive medications (azathioprine, methotrexate, mycophenolate mofetil), biologics, or plasma exchange can be considered

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Targeting NLRP3 inflammasome activation has direct translational relevance: the small-molecule inhibitor MCC950 ameliorates albuminuria, glomerulosclerosis, and podocyte injury in db/db mice by blocking caspase-1/IL-1 maturation

To the 10.000 rpm supernatant containing microsomes and cytosol fractions, 0.2 volume of 0.1 M calcium chloride solution was added, and further centrifuged at 10,000 rpm for 10 minutes to precipitate the microsomes

They may present an oval, triangular, or rounded morphology and may be flat or slightly concave (koilonychia) (Fig

& Salomone, S