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Elevated levels of CHAC1, often induced by ER stress, lead to reduced GSH levels, increased oxidative stress, and greater vulnerability to cell death processes like ferroptosis

doi: 10.1016/j.celrep.2019.07.043

At physiologic pH (such as in serum and joint tissues), uric acid (which is a weak acid) exists as the anion urate, and plasma protein binding is quite low for urate

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Esterified AA is hydrolysed by phospholipase A 2 into a free form that is further metabolized by COX, LOX and CYP450 to a wide range of bioactive mediators, including prostaglandins, lipoxins, thromboxanes, leukotrienes, hydroxyeicosatetraenoic acids and epoxyeicosatrienoic acids

They achieve this by partially disrupting the balance of certain chemicals in cells to eliminate tumor cells and reverse resistance