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A fibroblast activation protein -activatable nanoagent co-delivering diethyldithiocarbamate and copper for tumor therapy and imaging

Endothelin, which can originate from local tissues, increases intraluminal pressure by increasing outflow resistance, contracting retinal veins in particular where they exit the eye (for review of this mechanism in retina, see also 7,8 Elevated RVP has been associated with endothelial dysfunction and impaired vascular regulation, with recent studies indicating that diminished patency of blood vessels plays a key role in the increase of retinal venous pressure and subsequent edema

SFN upregulated Nrf2 expression and its downstream gene NQO1, reduced the inflammatory mediator NLRP3, and mitigated Su5416 and hypoxia (SuHx)-induced RV remodeling (Wang Y

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PLoS ONE 9:e109817

Full responsibility for the editorial process for this article was delegated to Co-Editor Carlos L