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NAD+ or SS-31 improved mitochondrial repair and oxidative resilience

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Furthermore, treatment with ALA also led to a significant improvement in seminal levels of total antioxidant capacity compared to placebo, demonstrating an improvement in the quality of seminal parameters after ALA treatment

The different effects observed between ambient heat stress and in vitro heat stress may be caused by the differences in the responses of both models to high temperatures

Notably, PGE2 suppresses the activation and activity of T cells by enhancing PD-L1 expression and the polarization of TAMs through cAMP and mitochondrial signals, thereby forming a positive feedback cycle [62, 63]

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