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the GHK-Cu complex operates through dozens of mechanisms simultaneously collagen synthesis, ECM organization, MMP suppression, antioxidant defense, and gene expression modulation across ~4,000 targets

16(2): 1048-1059 Research Article 10.5455/OVJ.2026.v16.i2.25 Department of Animal Production Technology, Faculty of Animal Science, Universitas Andalas, Padang, Indonesia *Corresponding Author: Tinda Afriani

ME2 deficiency in melanoma cells results in decreased ATP levels and increased ROS levels, which triggers AMP-activated protein kinase (AMPK) activity, promoting p53 phosphorylation and activation, and ultimately cell death 20

Also, the nanocomplex of selenium and the polysaccharide component of Pholiota adiposa significantly elevates the levels of CD3+ CD4+ T cells and CD3+ CD8+ T cell in H22 tumor-bearing mice (122)