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Matsudaira T, Nakano S, Konishi Y et al (2023) Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype

Chronic 5-HT 2B R activation has been linked with valvular heart disease, 24,25 and so the binding of speciogynine, paynantheine, and their 9- O -desmethyl metabolites to 5-HT 2B R raised the question of a potential cardiovascular risk to chronic kratom users