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Some people take higher than the recommended daily dose of paracetamol for pain over several days

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More importantly, a growing body of research reveals that these hepatoprotective effects do not stem from direct liver-targeted actions of TCM components but are achieved through an indirect pharmacological model: TCM acts as a 'modulator' to reshape the GM structure, which subsequently alters the profile and levels of microbiota-derived intermediary substances (e.g., metabolites such as SCFAs, BAs, TMAO, LPS, etc.)

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We also observed an increase in the intracellular levels of homocysteine in the iRBC as compared to nRBC (Fig

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33 The side effects include myalgias, arthralgia, sinusitis, fever, and flu-like symptoms

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Herrera & Ortega-Senovilla, 2017)

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The sponsor (Orphalan, France) planned to use NCC-Ex(3) to guide treatment and as primary endpoint

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