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As a selenium-dependent enzyme, GPX4 specifically catalyzes the reduction of phospholipid hydroperoxides by reduced GSH, converting toxic lipid peroxides into non-toxic lipid alcohols to maintain plasma membrane integrity [64, 65]

Many researchers believe that aging is actually caused by free radical damage and that depleted glutathione levels might be responsible for oxidative damage to our DNA. Levels tend to drop after age 45, a correlation that might explain the cellular damage we can blame for making us feel older

TRIM9 short isoform preferentially promotes DNA and RNA virus-induced production of type I interferon by recruiting GSK3 to TBK1

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Boratyn GM, Camacho C, Cooper PS, Coulouris G, Fong A, Ma N, et al