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Implication of oxidative stress in progression of diabetic retinopathy

Increased airway epithelial Na + absorption produces cystic fibrosis-like lung disease in mice

This interaction prevents their binding to Parkin, an E3 ubiquitin ligase, thereby maintaining the protein stability of both PHGDH and FXR1 ( Accumulation of FXR1 further enhances the stability of PSAT1 mRNA and promotes its translation, ultimately upregulating the expression of PHGDH and PSAT1 and activating the de novo serine synthesis pathway

However, BAs can also induce analgesic effects by binding to TGR5 on DRG neurons 63

Furthermore, inhibition of Rac1 with NSC23766 or Rac1-siRNA suppressed NADPH oxidase activity, reduced ROS levels, downregulated CD36 expression, and preserved -cell viability, highlighting the Rac1-CD36 axis as a potential therapeutic target for preventing glucose-induced -cell dysfunction [64]

PMID: 46 TufailMJiangCLiN