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9 Toxicology and side effects Current evidence reveals an intrinsic paradox between therapeutic efficacy and safety profiles of bioactive compounds - no identified pharmacologically active agent completely avoids non-specific off-target effects on healthy tissues ( in vitro study demonstrated that shikonin has potent cytotoxicity against 15 types of cancer cells through mitochondrial dysfunction and can induce apoptosis

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Hydroperoxides can then be reduced to form hydroxyl intermediates (HETE and hydroxy-octadecadienoic acid (HODE)) and further dehydrogenated to form ketone intermediates (oxo-eicosatetraenoic acid (oxoETE) and oxo-octadecadienoic acid (oxoODE)) ( Reference Yuan, Rapoport and Soldin 62 )

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Speliotes 4 , (1)University of Michigan School of Medicine, (2)University of Michigan, (3)University of Michigan, Ann Arbor, MI, (4)University of Michigan Medical School Background: Primary hepatocytes are difficult to obtain and dedifferentiate quickly in cell culture making them challenging to use to model chronic liver disease

The multidimensional mechanisms of hyperbaric oxygen (HBO) therapy in cerebral ischemic-hypoxic injury are becoming increasingly elucidated