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In turn, the peroxynitrites inactivate the precursor of nitric oxide synthase (NOS) by increasing the uncoupling of the enzyme creating a greater quantity of O2 - (peroxide) than of NO (47-49)

10.1021/acs.analchem.0c02298

(2022) where normalization of NO levels with LC was reported in models of reproductive stress induced by deleterious chemicals

Nat Commun 12 , 2670 (2021)

doi: 10.1016/j.jiph.2023.05.026 11 AnupongW.On-UmaR.JutamasK.SalmenS

Budzynska B, Wnorowski A, Kaszubska K, Biala G, Kruk-Somka M, Kurzepa J, Boguszewska-Czubara A (2018) Acute MDMA and nicotine co-administration: behavioral effects and oxidative stress processes in mice