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ROS Scavenging and Gene Regulation: Oxidative stress upregulates the Microphthalmia-associated Transcription Factor (MITF), which acts as the primary on-switch for melanin production [5]

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What I focus on with nitrofurantoin patients is the practical picture: alcohol irritates the bladder, causes dehydration which concentrates urine, and suppresses the immune function that matters when you are fighting a UTI