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References Xu C, Liu WB, Zhang DD, Shi HJ, Zhang L, Li XF

Retinoic acid and immune homeostasis: a balancing act

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DiToro D, Harbour SN, Bando JK, Benavides G, Witte S, Laufer VA, Moseley C, Singer JR, Frey B, Turner H, Bruning J, Darley-Usmar V, Gao M, Conover C, Hatton RD, Frank S, Colonna M, Weaver CT

In the cytosol/nucleus, SOD1, Prx1/2, GPx1/4 and the Grx/Trx1 systems, supported by abundant GSH, confine ROS and tune thiol switches on enzymes and transcriptional regulators while DNA repair machineries such as OGG1 and the base-excision repair (BER) pathway continuously survey and correct oxidative lesions, together establishing a compartment-aware redox homeostasis that enables signaling yet limits collateral damage (Le Gal et al

Dietary Sources Niacin is found in both plants and animals