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and finally, the results were further verified by a natural senescence model

These key molecules not only provide novel perspectives for elucidating AD pathogenesis but also offer potential targets for developing new neuroprotective agents (223)

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 contain a glutathione, cysteinylglycine, or cysteine group conjugated to the eicosanoid backbone at position 6 and are produced predominantly by mast cells, eosinophils, and basophils

Plasma half-life in animal pharmacokinetic studies runs approximately 2 hours, with roughly 20% intranasal bioavailability and primary urinary excretion