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Thus, glutamine plays an important role in the process of metabolism in tumor cells

doi: 10.1038/s41598-022-16372-3 35 WuYJiaQTangQDengHHeYTangF

Glutathione exists in cells in two states: reduced (GSH) and oxidized (GSSG)

Toxins 5 (11), 22812292

Its initiation depends on intracellular iron overload, which serves as the key biochemical basis and trigger, ultimately leading to extensive membrane damage

556 Consequently, researchers believe that HIF-1 may serve as a mechanism for cells to rapidly respond to acute hypoxia, whereas HIF-2 may be more relevant in chronic hypoxic responses