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Furthermore, genome-wide CRISPR screening identified SEC24 homolog B (SEC24B) as a key regulator of ferroptosis, and its knockout significantly inhibited ferroptosis in microglia (Ryan et al., 2023b)

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Sirtuin 1 (SIRT1) and the insulin-like growth factor receptor (IGFR) are among the most pharmacologically relevant, although not exhaustive, examples of stimulators of the HSF1HSP70 axis (Vihervaara and Sistonen, 2014