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Strher DJ, de Oliveira MF, Martinez-Oliveira P, Pilar BC, Cattelan MDP, Rodrigues E, Bertolin K, Gonalves PBD, Piccoli JDCE, Manfredini V

Among patients of East Asian ancestry (i.e., Chinese, Japanese, Vietnamese), 2% have two loss-of-function alleles of the NUDT15 gene, and approximately 21% have one loss-of-function allele

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Depletion of both CBS and CSE causes hyperhomocystenaemia, which is an independent risk factor for developing cardiovascular deficits and neurodegenerative disorders such as Alzheimer's disease (Mattson and Shea, 2003

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After incubation in the dark at 4 C for 2 days, plates were cultivated in a growth chamber at 22 C with a 16 h/8 h light/dark (long day, LD) photoperiod