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Organoids derived from ectopic endometriosis lesions have shown promising utility in modeling disease-specific characteristics, including the altered expression of ECM-receptor interaction genes ( COL3A1 , FN1 , ITGA11 , LAMA2 ), WNT-pathway genes ( CTNNA2 , LEF1 , WNT11) and hormone-responsive genes ( HSD11B1 , LIFR , PGR , PRLR ) [40, 55, 64]