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Before CoQ 10 emerged as a ferroptosis suppressor, it was primarily viewed as an essential electron carrier in the mitochondrial electron transport chain (ETC), shuttling electrons from complexes I/II to complex III to maintain oxidative phosphorylation 18

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also showed the same trend in knee symptoms and daily activity progression using the mean KOOS score in ten participants with degenerative meniscus tears without osteoarthritis according to Stoller classification after 3 months and 6 months of follow up (i.e., KOOS: 56.6 15.7 baseline, 70.2 16.8 post- 3 months, 72.7 18.5 post- 6 months, p = 0.0007)

Consistent with these findings, HIF-1 and NRF2 expression levels are mutually associated, and high levels of these transcription factors correlate with poor outcomes in glioblastoma patients 90

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Antioxidants such as vitamin E and the enzyme GPX4 play crucial roles in shielding these cells by mitigating lipid peroxidation and bolstering their resistance to oxidative stress (167)