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Widespread siRNA off-target transcript silencing mediated by seed region sequence complementarity

In conclusion, there was rapid conversion of hydroxyzine to cetirizine

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Spitzer et al., 2017

Dysregulated NLRP3 produces pro-inflammatory cytokines, IL-1 and IL-18, which serve to exacerbate myocardial damage initiating widespread inflammation within the cardiac tissue The activation of the NLRP3 inflammasome is related to several high-risk factors of DCM such as hyperlipidaemia, diabetes, obesity and hyperhomocysteinemia (100)

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